Genetic instability and clonal expansion
نویسندگان
چکیده
منابع مشابه
Genetic instability and clonal expansion.
Inactivation of tumor suppressor genes can lead to clonal expansion. We study the evolutionary dynamics of this process and calculate the probability that inactivation of a tumor suppressor gene is preceded by mutations in genes that confer genetic instability. Unstable cells might have a slower rate of clonal expansion than stable cells because of an increased probability of generating lethal ...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2006
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2005.11.012